Group Leader – Evolutionary Developmental Biology Laboratory

The Francis Crick Institute, London, U.K.

Postdoctoral Fellow at the Center for Molecular Biology (ZMBH)

University of Heidelberg, Heidelberg, Germany

Advisor: Prof. Henrik Kaessman

Marie Curie Fellow at the Center for Integrative Genomics

University of Lausanne, Lausanne, Switzerland

Advisor: Prof. Henrik Kaessman

Postdoctoral Fellow at the Department of Molecular Biology and Genetics

Cornell University, Ithaca, USA

Advisor: Prof. Andrew G. Clark

Visiting PhD student at the Department Ecology and Evolution

The University of Chicago, Chicago, USA

Advisor: Prof. Manyuan Long

Ph.D. in Evolutionary Genetics

University of Porto, Porto, Portugal

The University of Chicago - Department of Ecology and Evolution, Chicago, USA

Advisor: Prof. Manyuan Long

B.S. degree in Biology (Summa cum Laude)

University of Porto, Porto, Portugal

Otto-Schmeil Prize (Heidelberg Academy of Sciences)

Marie Curie postdoctoral fellowship (European commission)

Novartis postdoctoral fellowship (Switzerland)

Foundation for Science and Technology postdoctoral fellowship (Portugal)

Travel awards (USA & Europe)

Genetics Society of America (2 awards), Keystone Symposia, DIMACS (Rutgers University), Society for Molecular Biology and Evolution, European Society for Evolutionary Developmental Biology

GABBA Ph.D. fellowship (Portugal)

Engenheiro António de Almeida Foundation award for outstanding undergraduate academic performance (Portugal)

Merit Scholarship for outstanding undergraduate academic performance (University of Porto, Portugal)

Cardoso-Moreira M.^¶, Velten B., Mort M., Cooper D. N., Huber W. and Kaessmann H.^¶ Developmental gene expression differences between humans and mammalian models. bioRxiv

Wang Z.Y., Leushkin E., Liechti A., Ovchinnikova S., Mößinger K., Brüning T., Rummel C., Grützner F., Cardoso-Moreira M., Janich P., Gatfield D., Diagouraga B., de Massy B., Gill M.E., Peters A.H.F.M., Anders S., and Kaessmann H. Transcriptome and translatome co-evolution in mammals. Nature (in press)

Cardoso-Moreira M.^¶, Halbert J., Valloton D., Velten B., Chen C., Shao Y., Liechti A., Ascencao K., Rummel C., Ovshinnikova S., Mazin P. V., Xenarios I., Harshman K., Mort M., Cooper D. N., Sandi C., Soares M., Ferreira P. G., Afonso S., Carneiro M., Turner J. A., VandeBerg J. L., Fallashahroudi A., Jensen P., Behr R., Lisgo S., Lindsay S., Khaitovich P., Huber W., Baker J. C., Anders S., Zhang Y. E. and Kaessmann H.^¶ Gene expression across mammalian organ development. Nature 26-06-2019.

Sarropoulos I., Marin R., Cardoso-Moreira M.*^¶ and Kaessmann H.*^¶ Developmental dynamics of lncRNAs across mammalian organs and species. Nature 26-06-2019.

Hannibal R. L., Cardoso-Moreira M., Chetty S. P., Lau J., Qi Z, Gonzalez-Maldonado E., Cherry A. M., Yu J, Norton M. E., Baker J. C. Investigating human placentation and pregnancy using first trimester chorionic villi. Placenta 65:65-75.

Early A. M., Arguello J. R., Cardoso-Moreira M., Gottipati S., Grenier J. K. and Clark A. G. Survey of global genetic diversity within the Drosophila immune system. Genetics 205:353-366.

Tan S., Cardoso-Moreira M., Shi W., Zhang D., Huang J., Mao Y., Jia H., Zhang Y., Chen C., Shao Y., Leng L., Liu Z., Huang X., Long M. and Zhang Y. E. LTR-mediated retroposition as a mechanism of RNA-based duplication in metazoans. Genome Research 26:1663-1675.

Cardoso-Moreira M.^¶, Arguello J. R., Gottipati S., Harshman L. G., Grenier J. K. and Clark A. G. Evidence for the fixation of gene duplications by positive selection in Drosophila. Genome research 26:787-798.

Arguello J. R., Cardoso-Moreira M., Mohammed J., Grenier J. K., Gottipati S., Clark A. G. and Benton R. Extensive local adaptation within the chemosensory system following D. melanogaster’s global expansion. Nature communications 7:11855.

Grenier J. K., Arguello J. R., Cardoso-Moreira M., Gottipati S., Mohammed J., Hackett S. R., Boughton R., Greenberg A. J. and Clark A. G. Global Diversity Lines - A five-continent reference panel of sequenced Drosophila melanogaster strains. G3 5 (4), 593-603.

Covered in Genes to Genomes (Genetics Society of America).

Cardoso-Moreira M.^¶, Arguello J. R. and Clark A.G. Mutation spectrum of Drosophila CNVs revealed by breakpoint sequencing. Genome Biology 13:R119.

Cardoso-Moreira M.^¶ and Long M. The origin and evolution of new genes. Evolutionary genomics: statistical and computational methods Springer (Humana).

Cardoso-Moreira M.^¶, Emerson J.J., Clark A.G. and Long M. Drosophila duplication hotspots are associated with late-replicating regions of the genome. PLoS Genetics 7:e1002340.

Cardoso-Moreira M.^¶ and Long M. Mutational bias shaping fly copy number variation: implications for genome evolution. Trends in Genetics 26:243-247.

Emerson J.J.*^¶, Cardoso-Moreira M.*^¶, Borevitz J. and Long M. Natural selection shapes genome-wide patterns of copy number polymorphism in Drosophila melanogaster. Science 320:1629-1631.

Master thesis mentor to Leticia Rodríguez Montes

University of Heidelberg, Germany

Ph.D. mentor to Ioannis Sarropoulos. The role of lncRNAs in mammalian development

University of Heidelberg, Germany

Ph.D. mentor to Tania Studer. The developmental profiles of X and Y genes during organ development

University of Heidelberg, Germany

Master thesis mentor to Ioannis Sarropoulos

University of Heidelberg, Germany

Awarded The Society for Biochemistry and Molecular Biology outstanding Master's thesis in the fields of Molecular Biosciences and Molecular Biotechnology.

Teaching assistant, Frontiers - section on Genome structure and evolution

University of Heidelberg, Germany

Masters level.

Teaching assistant, Molecular Evolution course

University of Lausanne, Switzerland

Undergraduate level.

Guest lecturer for Human Genomics

Cornell University, Ithaca, USA

Undergraduate and graduate levels.

EMBO | EMBL Symposium: The Molecular Basis and Evolution of Sexual Dimorphism, Heidelberg, Germany.

University of Wisconsin, Madison, USA.

University of Pittsburgh, Pittsburgh, USA.

University of Minnesota, Minneapolis, USA.

University of Southern California, Los Angeles, USA.

Rockefeller University, New York, USA.

UT Southwestern, Dallas, USA.

University of Washington, Seattle, USA.

Uconn Health, Farmington, USA.

University of Massachusetts Medical School, Worcester, USA.

NYU Langone, New York, USA.

Sloan Kettering Institute, New York, USA.

The Francis Crick Institute, London, UK.

Durham University, Durham, UK.

Animal Genetics and Disease conference, Wellcome Genome Campus, UK.

IST Austria, Vienna, Austria.

DKFZ/ZMBH Allianz-Young Scientist Seminar, Heidelberg, Germany.

Alliance retreat (interdepartmental seminars), Kloster Schöntal, Germany.

Illumina Symposium on Advances in Genome Science, Lausanne, Switzerland.

Symposium on Next Generation Comparative Phylogenomics. Swiss Institute of Bioinformatics and Conference Universitaire de Suisse Occidentale, Geneva, Switzerland.

Innovation and conservation during mammalian organ development.

Talk: Evolution Meeting, Montpellier, France.

Developmental constraints in the evolution of mammalian organs.

Talk: Euro Evo Devo Meeting, Galway, Ireland.

Conservation and innovation during mammalian organ development.

Poster: 2nd Biennial Meeting Pan-American Society for Evolutionary Developmental Biology, Calgary, Canada.

The evolution of mammalian gene expression across time.

Talk: Annual Meeting of the Society of Molecular Biology and Evolution (SMBE), Austin, USA.

The evolution of developmental gene expression programs in mammals.

Talk: EMBO Meeting, Mannheim, Germany.

The evolution of developmental gene expression programs in mammals.

Talk: Euro Evo Devo Meeting, Uppsala, Sweden.

Fixation of gene duplications due to beneficial increases in gene expression.

Talk: Meeting of the European Society for Evolutionary Biology (ESEB), Lausanne, Switzerland.

Fixation of gene duplications due to beneficial increases in gene expression.

Talk: Annual Meeting of the Society of Molecular Biology and Evolution (SMBE), Vienna, Austria.

Positive selection drives gene duplications to fixation in drosophila.

Poster: European Evo Devo Meeting, Vienna, Austria.

The polymorphic stage of new gene evolution.

Talk: Annual Meeting of the Society of Molecular Biology and Evolution (SMBE), Chicago, USA.

The impact of mutational biases and positive selection on the distribution of Copy Number Variants among five worldwide populations of Drosophila melanogaster.

Talk: 53rd Annual Drosophila Research Conference (Fly Meeting), Chicago, USA.

Natural selection shapes genome wide patterns of copy number polymorphism in Drosophila melanogaster.

Poster: Keystone Symposium on The Functional Consequences of Structural Variation in the Genome, Steamboat Springs, USA.

The roles of mutation and selection on copy number variation: lessons from two fly genomes.

Poster: 51th Annual Drosophila Research Conference (Fly meeting), Washington D.C., USA.

Biased mutational processes influence the genomic composition of copy number variation in Drosophila melanogaster.

Poster: 50th Annual Drosophila Research Conference (Fly meeting), Chicago, USA.

Natural selection shapes genome wide patterns of copy number polymorphism in Drosophila melanogaster.

Talk: International Congress of Genetics Meeting, Berlin, Germany.

Genome architecture and natural selection shape patterns of copy number polymorphism in Drosophila melanogaster.

Talk: Annual Meeting of the Society of Molecular Biology and Evolution (SMBE), Barcelona, Spain.

Natural selection shapes genome wide patterns of copy number polymorphism in Drosophila melanogaster.

Talk: III Meeting of Portuguese researchers in Evolutionary Biology, Lisbon, Portugal.

Evolutionary forces acting on copy-number variation in natural populations of Drosophila melanogaster.

Talk: 20th European Drosophila Research Conference, Viena, Austria.

Natural selection shapes levels and patterns of copy number polymorphisms in the Drosophila melanogaster genome.

Poster: Mechanisms of Genome Evolution (American Genetics Association Annual Symposium), Indiana University, USA.